SCOPe 2.05: Domain d2ab2a_: 2ab2 A:

Lineage for d2ab2a_ (2ab2 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (138 PDB entries)

8. Domain d2ab2a_: 2ab2 A: [203435]
   automated match to d2aa6b_
   complexed with snl, so4; mutant

Details for d2ab2a_

PDB Entry: 2ab2, 1.85 Å

PDB Description: mineralocorticoid receptor double mutant with bound spironolactone

PDB Compounds: (A:) Mineralocorticoid receptor

SCOPe Domain Sequences for d2ab2a_:

Sequence, based on SEQRES records:

>d2ab2a_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvk
wakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhq
samyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyike
lrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlve
iisdqlpkvesgnakplyfh

Sequence, based on observed residues (ATOM records):

>d2ab2a_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvk
wakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhq
samyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyike
lrkmvtkcnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlvei
isdqlpkvesgnakplyfh

Timeline for d2ab2a_:

• d2ab2a_ first appeared in SCOPe 2.03
  
• d2ab2a_ appears in SCOPe 2.04
  
• d2ab2a_ appears in SCOPe 2.06
  
• d2ab2a_ appears in the current release, SCOPe 2.08