SCOPe 2.06: Domain d1zp4c_: 1zp4 C:

Lineage for d1zp4c_ (1zp4 C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

8. Domain d1zp4c_: 1zp4 C: [203357]
   automated match to d1b5tb_
   complexed with c2f, fad, so4; mutant

Details for d1zp4c_

PDB Entry: 1zp4, 1.85 Å

PDB Description: glu28gln mutant of e. coli methylenetetrahydrofolate reductase (oxidized) complex with methyltetrahydrofolate

PDB Compounds: (C:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d1zp4c_:

Sequence, based on SEQRES records:

>d1zp4c_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfqffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppgsgkpemyasdlvtllke
vadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsa
gidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmv
kilsregvkdfhfytlnraemsyaichtlgvrp

Sequence, based on observed residues (ATOM records):

>d1zp4c_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfqffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlpemyasdlvtllkevadfdi
svaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsagidvei
ipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmvkilsre
gvkdfhfytlnraemsyaichtlgvrp

Timeline for d1zp4c_:

• d1zp4c_ first appeared in SCOPe 2.03
  
• d1zp4c_ appears in SCOPe 2.05
  
• d1zp4c_ appears in SCOPe 2.07
  
• d1zp4c_ appears in the current release, SCOPe 2.08