SCOPe 2.04: Domain d1oakl1: 1oak L:1-107

Lineage for d1oakl1 (1oak L:1-107)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (213 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1oakl1: 1oak L:1-107 [20290]
   Other proteins in same PDB: d1oaka_, d1oakh1, d1oakh2, d1oakl2
   part of Fab NMC-4 blocking the von willebrand factor (vwf) a1 domain function

Details for d1oakl1

PDB Entry: 1oak, 2.2 Å

PDB Description: crystal structure of the von willebrand factor (vwf) a1 domain in complex with the function blocking nmc-4 fab

PDB Compounds: (L:) nmc-4 igg1

SCOPe Domain Sequences for d1oakl1:

Sequence; same for both SEQRES and ATOM records:

>d1oakl1 b.1.1.1 (L:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
diqmtqspsslsaslgdrvtiscsasqdinkylnwyqqkpdgavkllifytsslhsgvps
rfsgsgsgtdysltisnlepediatyycqqyeklpwtfgggtklevk

Timeline for d1oakl1:

• d1oakl1 first appeared (with stable ids) in SCOP 1.55
  
• d1oakl1 appears in SCOPe 2.03
  
• d1oakl1 appears in SCOPe 2.05
  
• d1oakl1 appears in the current release, SCOPe 2.08