SCOPe 2.07: Domain d4hw3l1: 4hw3 L:172-323

Lineage for d4hw3l1 (4hw3 L:172-323)

1. Root: SCOPe 2.07

2. Class f: Membrane and cell surface proteins and peptides [56835] (60 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein automated matches [190236] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188722] (88 PDB entries)

8. Domain d4hw3l1: 4hw3 L:172-323 [202502]
   Other proteins in same PDB: d4hw3a2, d4hw3b2, d4hw3c2, d4hw3d2, d4hw3e2, d4hw3f2, d4hw3g2, d4hw3h2, d4hw3i2, d4hw3k2, d4hw3l2
   automated match to d4hw3k_
   complexed with 19g

Details for d4hw3l1

PDB Entry: 4hw3, 2.4 Å

PDB Description: Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

PDB Compounds: (L:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4hw3l1:

Sequence, based on SEQRES records:

>d4hw3l1 f.1.4.1 (L:172-323) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhved

Sequence, based on observed residues (ATOM records):

>d4hw3l1 f.1.4.1 (L:172-323) automated matches {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgkpmgrsgatsrkaletlrrvgdgvqrnhetafqgmlrkl
dikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesit
dvlvrtkrdwlvkqrgwdgfveffhved

Timeline for d4hw3l1:

• d4hw3l1 first appeared in SCOPe 2.03, called d4hw3l_
  
• d4hw3l1 appears in SCOPe 2.06
  
• d4hw3l1 appears in the current release, SCOPe 2.08