SCOPe 2.06: Domain d4g3yl2: 4g3y L:108-214

Lineage for d4g3yl2 (4g3y L:108-214)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein automated matches [190374] (16 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187221] (698 PDB entries)

8. Domain d4g3yl2: 4g3y L:108-214 [202172]
   Other proteins in same PDB: d4g3yc_, d4g3yl1
   automated match to d1rhha2

Details for d4g3yl2

PDB Entry: 4g3y, 2.6 Å

PDB Description: Crystal structure of TNF-alpha in complex with Infliximab Fab fragment

PDB Compounds: (L:) infliximab Fab L

SCOPe Domain Sequences for d4g3yl2:

Sequence; same for both SEQRES and ATOM records:

>d4g3yl2 b.1.1.2 (L:108-214) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d4g3yl2:

• d4g3yl2 first appeared in SCOPe 2.03
  
• d4g3yl2 appears in SCOPe 2.05
  
• d4g3yl2 appears in SCOPe 2.07
  
• d4g3yl2 appears in the current release, SCOPe 2.08