SCOP 1.75: Domain d1ad9l1: 1ad9 L:1-107

Lineage for d1ad9l1 (1ad9 L:1-107)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88533] (52 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831
   SQ NA # Humanized antibody
   SQ NA # humanized antibody
   SQ NA # engineered antibody
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

8. Domain d1ad9l1: 1ad9 L:1-107 [20212]
   Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
   part of humanized Fab CTM01

Details for d1ad9l1

PDB Entry: 1ad9, 2.8 Å

PDB Description: igg-fab fragment of engineered human monoclonal antibody ctm01

PDB Compounds: (L:) igg ctm01 fab (light chain)

SCOP Domain Sequences for d1ad9l1:

Sequence; same for both SEQRES and ATOM records:

>d1ad9l1 b.1.1.1 (L:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}
diqmtqspstlsasvgdrvtitcrssksllhsngdtflywfqqkpgkapkllmyrmsnla
sgvpsrfsgsgsgteftltisslqpddfatyycmqhleypftfgqgtkvevkr

Timeline for d1ad9l1:

• d1ad9l1 first appeared (with stable ids) in SCOP 1.55
  
• d1ad9l1 appears in SCOP 1.73
  
• d1ad9l1 appears in SCOPe 2.01
  
• d1ad9l1 appears in the current release, SCOPe 2.08