SCOPe 2.08: Domain d4eoka1: 4eok A:1-297

Lineage for d4eoka1 (4eok A:1-297)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d4eoka1: 4eok A:1-297 [201896]
   Other proteins in same PDB: d4eoka2, d4eokb1, d4eokb2, d4eokc2, d4eokd1, d4eokd2
   automated match to d4eokc_
   complexed with 4sp, sgm

Details for d4eoka1

PDB Entry: 4eok, 2.57 Å

PDB Description: thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin a3 complex with the inhibitor nu6102

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4eoka1:

Sequence, based on SEQRES records:

>d4eoka1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Sequence, based on observed residues (ATOM records):

>d4eoka1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirlegvpstaireisllkelnhpniv
klldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglafchshrvl
hrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystav
diwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwa
rqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d4eoka1:

• d4eoka1 first appeared in SCOPe 2.03, called d4eoka_
  
• d4eoka1 appears in SCOPe 2.07