SCOP 1.71: Domain d2ap2c_: 2ap2 C:

Lineage for d2ap2c_ (2ap2 C:)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.2 [TaxId:10090] [88525] (35 PDB entries)

8. Domain d2ap2c_: 2ap2 C: [20180]
   Other proteins in same PDB: d2ap2b_, d2ap2d_
   part of P-glycoprotein-specific scFv C219

Details for d2ap2c_

PDB Entry: 2ap2, 2.4 Å

PDB Description: single chain fv of c219 in complex with synthetic epitope peptide

SCOP Domain Sequences for d2ap2c_:

Sequence; same for both SEQRES and ATOM records:

>d2ap2c_ b.1.1.1 (C:) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.2}
fvrdivmtqspssltvtagekvtmsckssqsllnsgnqknyltwyqqkpgqppklliywa
stresgvpdrftgsgsgtdftltissvqaedlavyycqndysypltfgagtklep

Timeline for d2ap2c_:

• d2ap2c_ first appeared (with stable ids) in SCOP 1.55
  
• d2ap2c_ appears in SCOP 1.69
  
• d2ap2c_ appears in SCOP 1.73
  
• d2ap2c_ appears in the current release, SCOPe 2.08, called d2ap2c1