SCOPe 2.08: Domain d4drjb1: 4drj B:2025-2114

Lineage for d4drjb1 (4drj B:2025-2114)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (29 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family)
   automatically mapped to Pfam PF08771

5. Family a.24.7.1: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47213] (2 proteins)

6. Protein mTOR FKBP12–rapamycin-binding (FRB) domain [47214] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47215] (11 PDB entries)

8. Domain d4drjb1: 4drj B:2025-2114 [201734]
   Other proteins in same PDB: d4drja_, d4drjb2
   automated match to d4drhe_
   complexed with rap, so4

Details for d4drjb1

PDB Entry: 4drj, 1.8 Å

PDB Description: o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR

PDB Compounds: (B:) Serine/threonine-protein kinase mTOR

SCOPe Domain Sequences for d4drjb1:

Sequence; same for both SEQRES and ATOM records:

>d4drjb1 a.24.7.1 (B:2025-2114) mTOR FKBP12–rapamycin-binding (FRB) domain {Human (Homo sapiens) [TaxId: 9606]}
emwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdlmeaqew
crkymksgnvkdltqawdlyyhvfrriskq

Timeline for d4drjb1:

• d4drjb1 first appeared in SCOPe 2.03, called d4drjb_
  
• d4drjb1 appears in SCOPe 2.07