SCOPe 2.07: Domain d4drhb1: 4drh B:2025-2112

Lineage for d4drhb1 (4drh B:2025-2112)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.24: Four-helical up-and-down bundle [47161] (28 superfamilies)
   core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

4. Superfamily a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family)
   automatically mapped to Pfam PF08771

5. Family a.24.7.1: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47213] (2 proteins)

6. Protein mTOR FKBP12–rapamycin-binding (FRB) domain [47214] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47215] (11 PDB entries)

8. Domain d4drhb1: 4drh B:2025-2112 [201732]
   Other proteins in same PDB: d4drha_, d4drhb2, d4drhd_, d4drhe2
   automated match to d4drhe_
   complexed with rap, so4

Details for d4drhb1

PDB Entry: 4drh, 2.3 Å

PDB Description: Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH

PDB Compounds: (B:) Serine/threonine-protein kinase mTOR

SCOPe Domain Sequences for d4drhb1:

Sequence; same for both SEQRES and ATOM records:

>d4drhb1 a.24.7.1 (B:2025-2112) mTOR FKBP12–rapamycin-binding (FRB) domain {Human (Homo sapiens) [TaxId: 9606]}
emwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdlmeaqew
crkymksgnvkdltqawdlyyhvfrris

Timeline for d4drhb1:

• d4drhb1 first appeared in SCOPe 2.03, called d4drhb_
  
• d4drhb1 appears in SCOPe 2.06
  
• d4drhb1 appears in the current release, SCOPe 2.08