SCOP 1.71: Domain d1aj7l1: 1aj7 L:1-109

Lineage for d1aj7l1 (1aj7 L:1-109)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (170 PDB entries)

8. Domain d1aj7l1: 1aj7 L:1-109 [20084]
   Other proteins in same PDB: d1aj7h1, d1aj7h2, d1aj7l2
   part of humanized Fab 48G7
   complexed with npe

Details for d1aj7l1

PDB Entry: 1aj7, 2.1 Å

PDB Description: immunoglobulin 48g7 germline fab antibody complexed with hapten 5-(para-nitrophenyl phosphonate)-pentanoic acid. affinity maturation of an esterolytic antibody

SCOP Domain Sequences for d1aj7l1:

Sequence; same for both SEQRES and ATOM records:

>d1aj7l1 b.1.1.1 (L:1-109) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4}
diqmtqspsslsaslgervsltcrasqeisgylswlqqkpdgtikrliyaastldsgvpk
rfsgsrsgsdysltisslesedfadyyclqyasyprtfgggtkveikrt

Timeline for d1aj7l1:

• d1aj7l1 first appeared (with stable ids) in SCOP 1.55
  
• d1aj7l1 appears in SCOP 1.69
  
• d1aj7l1 appears in SCOP 1.73
  
• d1aj7l1 appears in the current release, SCOPe 2.08