Lineage for d3s53a_ (3s53 A:)

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2799129Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2799130Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2799131Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
    dimer of identical mono-domain chains, each containing (6,10) barrel
  6. 2799147Protein Human immunodeficiency virus type 1 protease [50632] (9 species)
  7. 2799397Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
    Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167
  8. 2799618Domain d3s53a_: 3s53 A: [200582]
    automated match to d3s54a_
    complexed with 017, iod, po4; mutant

Details for d3s53a_

PDB Entry: 3s53 (more details), 1.5 Å

PDB Description: HIV-1 protease triple mutants V32I, I47V, V82I with antiviral drug darunavir in space group P212121
PDB Compounds: (A:) Protease

SCOPe Domain Sequences for d3s53a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3s53a_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmvggiggfikvrqyd
qiiieiaghkaigtvlvgptpiniigrnlltqigatlnf

SCOPe Domain Coordinates for d3s53a_:

Click to download the PDB-style file with coordinates for d3s53a_.
(The format of our PDB-style files is described here.)

Timeline for d3s53a_: