SCOPe 2.08: Domain d1nmch1: 1nmc H:9-113

Lineage for d1nmch1 (1nmc H:9-113)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (181 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1nmch1: 1nmc H:9-113 [20057]
   Other proteins in same PDB: d1nmca_, d1nmcb2, d1nmcc_, d1nmch2, d1nmcl_, d1nmcn_
   part of Fab NC10; only Fv coordinates are included
   complexed with ca, man, nag

Details for d1nmch1

PDB Entry: 1nmc, 2.5 Å

PDB Description: complex between nc10 anti-influenza virus neuraminidase single chain antibody with a 15 residue linker and influenza virus neuraminidase

PDB Compounds: (H:) single chain antibody

SCOPe Domain Sequences for d1nmch1:

Sequence; same for both SEQRES and ATOM records:

>d1nmch1 b.1.1.1 (H:9-113) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
aelvkpgasvrmsckasgytftnynmywvkqspgqglewigifypgngdtsynqkfkdka
tltadkssntaymqlssltsedsavyycarsggsyrydggfdywgqgttvtvss

Timeline for d1nmch1:

• d1nmch1 first appeared (with stable ids) in SCOP 1.55, called d1nmch_
  
• d1nmch1 appears in SCOPe 2.07