SCOPe 2.06: Domain d3dgab_: 3dga B:

Lineage for d3dgab_ (3dga B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)

8. Domain d3dgab_: 3dga B: [199233]
   Other proteins in same PDB: d3dgac_, d3dgad_
   automated match to d1j3ia_
   complexed with ndp, rj1, ump

Details for d3dgab_

PDB Entry: 3dga, 2.7 Å

PDB Description: wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump

PDB Compounds: (B:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d3dgab_:

Sequence, based on SEQRES records:

>d3dgab_ c.71.1.1 (B:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
meqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfcav
ttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtswesipkkfkplsn
rinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikk
iyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnn

Sequence, based on observed residues (ATOM records):

>d3dgab_ c.71.1.1 (B:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
meqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfcav
ttyvneskyeklkykrckylnketvdnskklqnvvvmgrtswesipkkfkplsnrinvil
srtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikkiyftri
nstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnn

Timeline for d3dgab_:

• d3dgab_ first appeared in SCOPe 2.03
  
• d3dgab_ appears in SCOPe 2.05
  
• d3dgab_ appears in SCOPe 2.07
  
• d3dgab_ appears in the current release, SCOPe 2.08