SCOPe 2.05: Domain d3dgaa_: 3dga A:

Lineage for d3dgaa_ (3dga A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (5 PDB entries)

8. Domain d3dgaa_: 3dga A: [199232]
   Other proteins in same PDB: d3dgac_, d3dgad_
   automated match to d1j3ia_
   complexed with ndp, rj1, ump

Details for d3dgaa_

PDB Entry: 3dga, 2.7 Å

PDB Description: wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump

PDB Compounds: (A:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d3dgaa_:

Sequence, based on SEQRES records:

>d3dgaa_ c.71.1.1 (A:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfca
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtswesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktn

Sequence, based on observed residues (ATOM records):

>d3dgaa_ c.71.1.1 (A:) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcnsldmkyfca
vttyvneskyeklkykrckylnkekklqnvvvmgrtswesipkkfkplsnrinvilsrtl
kkedfdedvyiinkvedlivllgklnyykcfiiggsvvyqeflekklikkiyftrinsty
ecdvffpeineneyqiisvsdvytsnnttldfiiykktn

Timeline for d3dgaa_:

• d3dgaa_ first appeared in SCOPe 2.03
  
• d3dgaa_ appears in SCOPe 2.04
  
• d3dgaa_ appears in SCOPe 2.06
  
• d3dgaa_ appears in the current release, SCOPe 2.08