SCOP 1.71: Domain d4fabl1: 4fab L:1-112

Lineage for d4fabl1 (4fab L:1-112)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (126 PDB entries)

8. Domain d4fabl1: 4fab L:1-112 [19906]
   Other proteins in same PDB: d4fabh1, d4fabh2, d4fabl2
   part of Fab 4-4-20
   complexed with fds, mpd

Details for d4fabl1

PDB Entry: 4fab, 2.7 Å

PDB Description: three-dimensional structure of a fluorescein-fab complex crystallized in 2-methyl-2,4-pentanediol

SCOP Domain Sequences for d4fabl1:

Sequence; same for both SEQRES and ATOM records:

>d4fabl1 b.1.1.1 (L:1-112) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1}
dvvmtqtplslpvslgdqasiscrssqslvhsqgntylrwylqkpgqspkvliykvsnrf
sgvpdrfsgsgsgtdftlkisrveaedlgvyfcsqsthvpwtfgggtkleik

Timeline for d4fabl1:

• d4fabl1 first appeared (with stable ids) in SCOP 1.55
  
• d4fabl1 appears in SCOP 1.69
  
• d4fabl1 appears in SCOP 1.73
  
• d4fabl1 appears in the current release, SCOPe 2.08