SCOPe 2.01: Domain d1fvcd_: 1fvc D:

Lineage for d1fvcd_ (1fvc D:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88562] (67 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody

8. Domain d1fvcd_: 1fvc D: [19865]
   Other proteins in same PDB: d1fvca_, d1fvcc_
   part of humanized Fv 4D5, herceptin

Details for d1fvcd_

PDB Entry: 1fvc, 2.2 Å

PDB Description: x-ray structures of the antigen-binding domains from three variants of humanized anti-p185-her2 antibody 4d5 and comparison with molecular modeling

PDB Compounds: (D:) igg1-kappa 4d5 fv (heavy chain)

SCOPe Domain Sequences for d1fvcd_:

Sequence; same for both SEQRES and ATOM records:

>d1fvcd_ b.1.1.1 (D:) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss

Timeline for d1fvcd_:

• d1fvcd_ first appeared (with stable ids) in SCOP 1.55
  
• d1fvcd_ appears in SCOP 1.75
  
• d1fvcd_ appears in SCOPe 2.02
  
• d1fvcd_ appears in the current release, SCOPe 2.08