SCOPe 2.06: Domain d2xkwa_: 2xkw A:

Lineage for d2xkwa_ (2xkw A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (113 PDB entries)
   Uniprot P37231 232-505

8. Domain d2xkwa_: 2xkw A: [198610]
   automated match to d1knua_
   complexed with epe, p1b, pe4

Details for d2xkwa_

PDB Entry: 2xkw, 2.02 Å

PDB Description: ligand binding domain of human ppar-gamma in complex with the agonist pioglitazone

PDB Compounds: (A:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d2xkwa_:

Sequence, based on SEQRES records:

>d2xkwa_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
lnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkik
fkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvh
eiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsd
laifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlr
qivtehvqllqvikktetdmslhpllqeiykdly

Sequence, based on observed residues (ATOM records):

>d2xkwa_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
lnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkke
vairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnk
dgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgd
rpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvi
kktetdmslhpllqeiykdly

Timeline for d2xkwa_:

• d2xkwa_ first appeared in SCOPe 2.03
  
• d2xkwa_ appears in SCOPe 2.05
  
• d2xkwa_ appears in SCOPe 2.07
  
• d2xkwa_ appears in the current release, SCOPe 2.08