SCOPe 2.08: Domain d2wxvb1: 2wxv B:176-309

Lineage for d2wxvb1 (2wxv B:176-309)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (88 PDB entries)
   Uniprot P20248 175-432

8. Domain d2wxvb1: 2wxv B:176-309 [198589]
   Other proteins in same PDB: d2wxva1, d2wxva2, d2wxvc1, d2wxvc2
   automated match to d1vywb1
   complexed with so4, wxv

Details for d2wxvb1

PDB Entry: 2wxv, 2.6 Å

PDB Description: structure of cdk2-cyclin a with a pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor

PDB Compounds: (B:) Cyclin-A2

SCOPe Domain Sequences for d2wxvb1:

Sequence; same for both SEQRES and ATOM records:

>d2wxvb1 a.74.1.1 (B:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaap

Timeline for d2wxvb1:

• d2wxvb1 first appeared in SCOPe 2.03
  
• d2wxvb1 appears in SCOPe 2.07