Lineage for d1fgvl_ (1fgv L:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2018294Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2018295Species Engineered (including hybrid species) [88533] (61 PDB entries)
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody
  8. 2018299Domain d1fgvl_: 1fgv L: [19852]
    Other proteins in same PDB: d1fgvh_
    part of humanized Fv H52

Details for d1fgvl_

PDB Entry: 1fgv (more details), 1.9 Å

PDB Description: x-ray structures of fragments from binding and nonbinding versions of a humanized anti-cd18 antibody: structural indications of the key role of vh residues 59 to 65
PDB Compounds: (L:) h52 fv (light chain)

SCOPe Domain Sequences for d1fgvl_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1fgvl_ b.1.1.1 (L:) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}

SCOPe Domain Coordinates for d1fgvl_:

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Timeline for d1fgvl_:

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