SCOPe 2.08: Domain d2pina_: 2pin A:

Lineage for d2pina_ (2pin A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48531] (22 PDB entries)
   Uniprot P10828 202-460

8. Domain d2pina_: 2pin A: [198255]
   automated match to d2pinb_
   complexed with 4hy, leg, so4

Details for d2pina_

PDB Entry: 2pin, 2.3 Å

PDB Description: thyroid receptor beta in complex with inhibitor

PDB Compounds: (A:) Thyroid hormone receptor Beta-1

SCOPe Domain Sequences for d2pina_:

Sequence, based on SEQRES records:

>d2pina_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
hkpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkvdleaf
shftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetlt
lngemavtrgqlkngglgvvsdaifrlgmslssfnlddtevallqavllmssdrpglacv
eriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecpte
lfpplflevfe

Sequence, based on observed residues (ATOM records):

>d2pina_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
hkpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapggkvdleafshftki
itpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlngema
vtrgqlkngglgvvsdaifrlgmslssfnlddtevallqavllmssdrpglacverieky
qdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelfpplf
levfe

Timeline for d2pina_:

• d2pina_ first appeared in SCOPe 2.03
  
• d2pina_ appears in SCOPe 2.07