SCOPe 2.03: Domain d2dwda1: 2dwd A:1-118

Lineage for d2dwda1 (2dwd A:1-118)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (177 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d2dwda1: 2dwd A:1-118 [197860]
   Other proteins in same PDB: d2dwda2, d2dwdb1, d2dwdb2, d2dwdc_
   automated match to d1r3jb1
   complexed with f09, l2c, tba, tl

Details for d2dwda1

PDB Entry: 2dwd, 2.6 Å

PDB Description: crystal structure of kcsa-fab-tba complex in tl+

PDB Compounds: (A:) antibody fab heavy chain

SCOPe Domain Sequences for d2dwda1:

Sequence; same for both SEQRES and ATOM records:

>d2dwda1 b.1.1.1 (A:1-118) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qvqlqqpgaelvkpgasvklsckasgytftsdwihwvkqrpghglewigeiipsygrany
nekiqkkatltadkssstafmqlssltsedsavyycarergdgyfavwgagttvtvss

Timeline for d2dwda1:

• d2dwda1 is new in SCOPe 2.03-stable
  
• d2dwda1 appears in SCOPe 2.04
  
• d2dwda1 appears in the current release, SCOPe 2.08