SCOPe 2.06: Domain d2b7dl1: 2b7d L:49-86

Lineage for d2b7dl1 (2b7d L:49-86)

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.11: EGF/Laminin [57196] (8 families)

5. Family g.3.11.1: EGF-type module [57197] (23 proteins)

6. Protein Coagulation factor VIIa [57201] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [57202] (96 PDB entries)
   Uniprot P08709 108-202 ! Uniprot P08709 107-202

8. Domain d2b7dl1: 2b7d L:49-86 [197778]
   Other proteins in same PDB: d2b7dh_, d2b7dt1, d2b7dt2
   automated match to d1danl1
   complexed with c1b

Details for d2b7dl1

PDB Entry: 2b7d, 2.24 Å

PDB Description: factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model

PDB Compounds: (L:) Coagulation factor VII

SCOPe Domain Sequences for d2b7dl1:

Sequence; same for both SEQRES and ATOM records:

>d2b7dl1 g.3.11.1 (L:49-86) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
qcasspcqnggsckdqlqsyicfclpafegrncethkd

Timeline for d2b7dl1:

• d2b7dl1 first appeared in SCOPe 2.03
  
• d2b7dl1 appears in SCOPe 2.05
  
• d2b7dl1 appears in SCOPe 2.07
  
• d2b7dl1 appears in the current release, SCOPe 2.08