Lineage for d8fabc1 (8fab C:3-105)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2019185Protein Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
  7. 2019263Species Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (7 PDB entries)
    Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  8. 2019265Domain d8fabc1: 8fab C:3-105 [19774]
    Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
    part of Fab HIL

Details for d8fabc1

PDB Entry: 8fab (more details), 1.8 Å

PDB Description: crystal structure of the fab fragment from the human myeloma immunoglobulin igg hil at 1.8 angstroms resolution
PDB Compounds: (C:) igg1-lambda hil fab (light chain)

SCOPe Domain Sequences for d8fabc1:

Sequence; same for both SEQRES and ATOM records: (download)

>d8fabc1 b.1.1.1 (C:3-105) Immunoglobulin light chain lambda variable domain, VL-lambda {Human (Homo sapiens), cluster 5 [TaxId: 9606]}

SCOPe Domain Coordinates for d8fabc1:

Click to download the PDB-style file with coordinates for d8fabc1.
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Timeline for d8fabc1: