SCOPe 2.05: Domain d4kina_: 4kin A:

Lineage for d4kina_ (4kin A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (162 PDB entries)

8. Domain d4kina_: 4kin A: [197336]
   automated match to d3zyaa_
   complexed with 1m8

Details for d4kina_

PDB Entry: 4kin, 1.97 Å

PDB Description: crystal structure of mitogen-activated protein kinase 14 (p38-h5) complex with 5-(2-chlorophenyl)-n-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-2-thiophenecarboxamide

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d4kina_:

Sequence, based on SEQRES records:

>d4kina_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d4kina_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnvkcqkltddh
vqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaryvatrwyrapeim
lnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisses
arnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdp
ddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d4kina_:

• d4kina_ first appeared in SCOPe 2.02
  
• d4kina_ appears in SCOPe 2.04
  
• d4kina_ appears in SCOPe 2.06
  
• d4kina_ appears in the current release, SCOPe 2.08