Lineage for d4hx5b_ (4hx5 B:)

  1. Root: SCOPe 2.02
  2. 1143363Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1150729Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1150730Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1151047Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 1151074Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 1151090Species Human (Homo sapiens) [TaxId:9606] [117424] (20 PDB entries)
    Uniprot P28845
  8. 1151112Domain d4hx5b_: 4hx5 B: [197314]
    automated match to d3pdjb_
    complexed with 19v, ndp

Details for d4hx5b_

PDB Entry: 4hx5 (more details), 2.19 Å

PDB Description: Crystal structure of 11 beta-HSD1 in complex with SAR184841
PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4hx5b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4hx5b_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflysts

SCOPe Domain Coordinates for d4hx5b_:

Click to download the PDB-style file with coordinates for d4hx5b_.
(The format of our PDB-style files is described here.)

Timeline for d4hx5b_:

  • d4hx5b_ appears in periodic updates to SCOPe 2.02 starting on 2013-06-13
  • d4hx5b_ appears in SCOPe 2.03
  • d4hx5b_ appears in the current release, SCOPe 2.07, called d4hx5b1