SCOPe 2.08: Domain d3zmga_: 3zmg A:

Lineage for d3zmga_ (3zmg A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d3zmga_: 3zmg A: [197289]
   automated match to d3kmxa_
   complexed with 6z0, dms, na

Details for d3zmga_

PDB Entry: 3zmg, 1.74 Å

PDB Description: crystal structure of bace-1 in complex with chemical ligand

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3zmga_:

Sequence, based on SEQRES records:

>d3zmga_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d3zmga_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplasvggsmiiggidh
slytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvf
eaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritil
pqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachv
hdefrtaavegpfvtldmedcgyni

Timeline for d3zmga_:

• d3zmga_ first appeared in SCOPe 2.02
  
• d3zmga_ appears in SCOPe 2.07