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Lineage for d3w69a_ (3w69 A:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1996222Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  4. 1996223Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families) (S)
    binds to the transactivation domain of human p53
  5. 1996224Family a.42.1.1: SWIB/MDM2 domain [47593] (5 protein domains)
    Pfam PF02201
  6. 1996231Protein MDM2 [47594] (2 species)
  7. 1996249Species Human (Homo sapiens) [TaxId:9606] [47596] (56 PDB entries)
  8. 1996304Domain d3w69a_: 3w69 A: [197281]
    automated match to d1rv1a_
    complexed with ltz, so4

Details for d3w69a_

PDB Entry: 3w69 (more details), 1.9 Å

PDB Description: Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor
PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d3w69a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3w69a_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
etlvrpkpellkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycsndllgd
lfgvpsfsvkehrkiytmiyrnlvv

SCOPe Domain Coordinates for d3w69a_:

Click to download the PDB-style file with coordinates for d3w69a_.
(The format of our PDB-style files is described here.)

Timeline for d3w69a_: