Lineage for d4jwra_ (4jwr A:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2321461Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
    core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
    duplication: consists of two structural repeats
  4. 2321462Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families) (S)
    binds to the transactivation domain of human p53
  5. 2321463Family a.42.1.1: SWIB/MDM2 domain [47593] (5 protein domains)
    Pfam PF02201
  6. 2321470Protein MDM2 [47594] (2 species)
  7. 2321488Species Human (Homo sapiens) [TaxId:9606] [47596] (60 PDB entries)
  8. 2321566Domain d4jwra_: 4jwr A: [197258]
    automated match to d4ereb_
    complexed with 1my

Details for d4jwra_

PDB Entry: 4jwr (more details), 2.35 Å

PDB Description: Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid
PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d4jwra_:

Sequence, based on SEQRES records: (download)

>d4jwra_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
ipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycs
ndllgdlfgvpsfsvkehrkiytmiyrnlvvv

Sequence, based on observed residues (ATOM records): (download)

>d4jwra_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
ipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndll
gdlfgvpsfsvkehrkiytmiyrnlvvv

SCOPe Domain Coordinates for d4jwra_:

Click to download the PDB-style file with coordinates for d4jwra_.
(The format of our PDB-style files is described here.)

Timeline for d4jwra_: