SCOPe 2.02: Domain d4hyha_: 4hyh A:

Lineage for d4hyha_ (4hyh A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)

8. Domain d4hyha_: 4hyh A: [196964]
   automated match to d2x8da_
   complexed with 1am

Details for d4hyha_

PDB Entry: 4hyh, 1.7 Å

PDB Description: X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d4hyha_:

Sequence, based on SEQRES records:

>d4hyha_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmln
henvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhg
igithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrre
fhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallh
kilvenpsaritipdikkdrwynkplkkg

Sequence, based on observed residues (ATOM records):

>d4hyha_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkenikkeicinkmlnhenvvk
fyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithr
dikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepv
dvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilven
psaritipdikkdrwynkplkkg

Timeline for d4hyha_:

• d4hyha_ is new in SCOPe 2.02-stable
  
• d4hyha_ appears in SCOPe 2.03
  
• d4hyha_ appears in the current release, SCOPe 2.08