SCOPe 2.05: Domain d4fgha_: 4fgh A:

Lineage for d4fgha_ (4fgh A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein automated matches [190514] (8 species)
   not a true protein

7. Species Staphylococcus aureus [TaxId:1280] [195885] (5 PDB entries)

8. Domain d4fgha_: 4fgh A: [196839]
   automated match to d3m08a_
   complexed with 0u6, gol, nap

Details for d4fgha_

PDB Entry: 4fgh, 2.5 Å

PDB Description: S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d4fgha_:

Sequence; same for both SEQRES and ATOM records:

>d4fgha_ c.71.1.1 (A:) automated matches {Staphylococcus aureus [TaxId: 1280]}
mtlsilvahdlqrvigfenqlpwhlpndlkhvkklstghtlvmgrktfesigkplpnrrn
vvltsdtsfnvegvdvihsiediyqlpghvfifggqtlfeemidkvddmyitviegkfrg
dtffppytfedwevassvegkldekntiphtflhlirkklvpr

Timeline for d4fgha_:

• d4fgha_ first appeared in SCOPe 2.02
  
• d4fgha_ appears in SCOPe 2.04
  
• d4fgha_ is called d4fgha1 in SCOPe 2.06
  
• d4fgha_ appears in the current release, SCOPe 2.08, called d4fgha1