SCOPe 2.07: Domain d4f45a1: 4f45 A:46-296

Lineage for d4f45a1 (4f45 A:46-296)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
   3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345

4. Superfamily c.23.14: N-(deoxy)ribosyltransferase-like [52309] (4 families)
   there are similar active site architectures as well as the catalytic mechanisms of functionally characterised members

5. Family c.23.14.3: ADP ribosyl cyclase-like [56630] (3 proteins)
   contains extra N-terminal all-alpha subdomain
   automatically mapped to Pfam PF02267

6. Protein ADP ribosyl cyclase [56631] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159490] (45 PDB entries)
   Uniprot P28907 45-291

8. Domain d4f45a1: 4f45 A:46-296 [196738]
   Other proteins in same PDB: d4f45a2, d4f45b2
   automated match to d2o3ta_
   complexed with dn4; mutant

Details for d4f45a1

PDB Entry: 4f45, 2.1 Å

PDB Description: Crystal structure of human CD38 E226Q mutant in complex with NAADP

PDB Compounds: (A:) ADP-ribosyl cyclase 1

SCOPe Domain Sequences for d4f45a1:

Sequence, based on SEQRES records:

>d4f45a1 c.23.14.3 (A:46-296) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefdt
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
qvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkfl
qcvknpedssc

Sequence, based on observed residues (ATOM records):

>d4f45a1 c.23.14.3 (A:46-296) ADP ribosyl cyclase {Human (Homo sapiens) [TaxId: 9606]}
wrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeed
yqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefdt
skinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsv
qvhnlqpekvqtleawvihggrdlcqdptikelesiiskrniqfsckniyrpdkflqcvk
npedssc

Timeline for d4f45a1:

• d4f45a1 first appeared in SCOPe 2.02, called d4f45a_
  
• d4f45a1 appears in SCOPe 2.06
  
• d4f45a1 appears in the current release, SCOPe 2.08