SCOPe 2.08: Domain d3r8ab1: 3r8a B:207-475

Lineage for d3r8ab1 (3r8a B:207-475)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (172 PDB entries)
   Uniprot P37231 232-505

8. Domain d3r8ab1: 3r8a B:207-475 [195833]
   Other proteins in same PDB: d3r8ab2
   automated match to d1rdtd_
   complexed with hig

Details for d3r8ab1

PDB Entry: 3r8a, 2.41 Å

PDB Description: X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity

PDB Compounds: (B:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d3r8ab1:

Sequence, based on SEQRES records:

>d3r8ab1 a.123.1.1 (B:207-475) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiykd

Sequence, based on observed residues (ATOM records):

>d3r8ab1 a.123.1.1 (B:207-475) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkkspfviydmnslmmevairifqgcqf
rsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvlisegqgf
mtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvkpie
diqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvhpllqeiykd

Timeline for d3r8ab1:

• d3r8ab1 first appeared in SCOPe 2.02, called d3r8ab_
  
• d3r8ab1 appears in SCOPe 2.07