SCOPe 2.03: Domain d3rvga_: 3rvg A:

Lineage for d3rvga_ (3rvg A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d3rvga_: 3rvg A: [195777]
   automated match to d3q32b_
   complexed with 17p

Details for d3rvga_

PDB Entry: 3rvg, 2.5 Å

PDB Description: crystals structure of jak2 with a 1-amino-5h-pyrido[4,3-b]indol-4- carboxamide inhibitor

PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d3rvga_:

Sequence, based on SEQRES records:

>d3rvga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

Sequence, based on observed residues (ATOM records):

>d3rvga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvspifwyapes
lteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknn
grlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

Timeline for d3rvga_:

• d3rvga_ first appeared in SCOPe 2.02
  
• d3rvga_ appears in SCOPe 2.04
  
• d3rvga_ appears in the current release, SCOPe 2.08