Lineage for d2ydka_ (2ydk A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1931583Protein automated matches [190091] (12 species)
    not a true protein
  7. 1931656Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)
  8. 1931733Domain d2ydka_: 2ydk A: [195651]
    automated match to d2x8da_
    complexed with gol, so4, ydk

Details for d2ydka_

PDB Entry: 2ydk (more details), 1.9 Å

PDB Description: discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2ydka_:

Sequence, based on SEQRES records: (download)

>d2ydka_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkml
nhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records): (download)

>d2ydka_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkrenikkeicinkmlnhenv
vkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigit
hrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhae
pvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilv
enpsaritipdikkdrwynkplk

SCOPe Domain Coordinates for d2ydka_:

Click to download the PDB-style file with coordinates for d2ydka_.
(The format of our PDB-style files is described here.)

Timeline for d2ydka_: