SCOPe 2.08: Domain d4afea1: 4afe A:3-271

Lineage for d4afea1 (4afe A:3-271)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4afea1: 4afe A:3-271 [195554]
   Other proteins in same PDB: d4afea2
   automated match to d2w5aa_
   complexed with edo, ggy

Details for d4afea1

PDB Entry: 4afe, 2.6 Å

PDB Description: Nek2 bound to hybrid compound 21

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOPe Domain Sequences for d4afea1:

Sequence, based on SEQRES records:

>d4afea1 d.144.1.7 (A:3-271) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfaktfvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenpli

Sequence, based on observed residues (ATOM records):

>d4afea1 d.144.1.7 (A:3-271) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrshrdlkpanvfldgkqnvklgdfglvgtpyymspeqmnrneksdiwslgcll
yelcalmppftafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeil
enpli

Timeline for d4afea1:

• d4afea1 first appeared in SCOPe 2.02, called d4afea_
  
• d4afea1 appears in SCOPe 2.07