Lineage for d4dfla1 (4dfl A:363-635)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545010Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 2545011Species Human (Homo sapiens) [TaxId:9606] [118132] (64 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 2545023Domain d4dfla1: 4dfl A:363-635 [195550]
    Other proteins in same PDB: d4dfla2
    automated match to d1xbaa_
    complexed with 0k0, edo, so4

Details for d4dfla1

PDB Entry: 4dfl (more details), 1.98 Å

PDB Description: crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4dfla1:

Sequence, based on SEQRES records: (download)

>d4dfla1 d.144.1.7 (A:363-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvvn

Sequence, based on observed residues (ATOM records): (download)

>d4dfla1 d.144.1.7 (A:363-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgtvkkgyyqmvvktvavkilpalkdellaeanvmqqldnpyiv
rmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvhr
dlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykfssks
dvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydv
enrpgfaavelrlrnyyydvvn

SCOPe Domain Coordinates for d4dfla1:

Click to download the PDB-style file with coordinates for d4dfla1.
(The format of our PDB-style files is described here.)

Timeline for d4dfla1:

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Domains from same chain:
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d4dfla2