SCOPe 2.02: Domain d3vapa_: 3vap A:

Lineage for d3vapa_ (3vap A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)

8. Domain d3vapa_: 3vap A: [195398]
   automated match to d3h10a_
   complexed with 0fy

Details for d3vapa_

PDB Entry: 3vap, 2.66 Å

PDB Description: Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity

PDB Compounds: (A:) Aurora kinase A

SCOPe Domain Sequences for d3vapa_:

Sequence, based on SEQRES records:

>d3vapa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrmh
dekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkh
npsqrpmlrevlehpwitanss

Sequence, based on observed residues (ATOM records):

>d3vapa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwgtldylppemiegrmhdekvdlwslgvlc
yeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlrevle
hpwitanss

Timeline for d3vapa_:

• d3vapa_ is new in SCOPe 2.02-stable
  
• d3vapa_ appears in SCOPe 2.03
  
• d3vapa_ appears in the current release, SCOPe 2.08