Lineage for d4er3a_ (4er3 A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2892669Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2892670Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families) (S)
  5. 2893876Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)
  6. 2893884Protein automated matches [191247] (1 species)
    not a true protein
  7. 2893885Species Human (Homo sapiens) [TaxId:9606] [189737] (31 PDB entries)
  8. 2893923Domain d4er3a_: 4er3 A: [195375]
    automated match to d1nw3a_
    complexed with 0qk, edo, so4, unx

Details for d4er3a_

PDB Entry: 4er3 (more details), 2.4 Å

PDB Description: crystal structure of human dot1l in complex with inhibitor epz004777
PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d4er3a_:

Sequence, based on SEQRES records: (download)

>d4er3a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhy
gvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnf
afgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsv
swtgkpvsyylhtidrtilenyfsslkn

Sequence, based on observed residues (ATOM records): (download)

>d4er3a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipak
yaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhql
kerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvsyylhtidrt
ilenyfsslkn

SCOPe Domain Coordinates for d4er3a_:

Click to download the PDB-style file with coordinates for d4er3a_.
(The format of our PDB-style files is described here.)

Timeline for d4er3a_: