SCOPe 2.08: Domain d3zs5a1: 3zs5 A:2-352

Lineage for d3zs5a1 (3zs5 A:2-352)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3zs5a1: 3zs5 A:2-352 [194989]
   Other proteins in same PDB: d3zs5a2
   automated match to d2baja_
   complexed with bog, edo, sb2

Details for d3zs5a1

PDB Entry: 3zs5, 1.6 Å

PDB Description: structural basis for kinase selectivity of three clinical p38alpha inhibitors

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3zs5a1:

Sequence, based on SEQRES records:

>d3zs5a1 d.144.1.7 (A:2-352) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqs
iihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqk
ltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtg
yvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgt
pgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaq
alahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d3zs5a1 d.144.1.7 (A:2-352) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqs
iihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqk
ltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglatrwyrapei
mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
sarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
pddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d3zs5a1:

• d3zs5a1 first appeared in SCOPe 2.02, called d3zs5a_
  
• d3zs5a1 appears in SCOPe 2.07