SCOPe 2.03: Domain d3tikd_: 3tik D:

Lineage for d3tikd_ (3tik D:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (33 species)
   not a true protein

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [194968] (6 PDB entries)

8. Domain d3tikd_: 3tik D: [194972]
   automated match to d3l4db_
   complexed with hem, jkf

Details for d3tikd_

PDB Entry: 3tik, 2.05 Å

PDB Description: Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

PDB Compounds: (D:) sterol 14-alpha demethylase (CYP51)

SCOPe Domain Sequences for d3tikd_:

Sequence; same for both SEQRES and ATOM records:

>d3tikd_ a.104.1.0 (D:) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
kgklppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivgkrvtivgdphehs
rfflprnevlsprevysfmvpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiq
hevrkfmaanwdkdegeinlledcstmiintacqclfgedlrkrldarrfaqllakmess
lipaavflpillklplpqsarcheartelqkilseiiiarkeeevnkdsstsdllsglls
avyrdgtpmslhevcgmivaamfagqhtssitttwsmlhlmhpanvkhlealrkeieefp
aqlnynnvmdempfaercaresirrdppllmlmrkvmadvkvgsyvvpkgdiiacsplls
hhdeeafpeprrwdperdekvegafigfgagvhkcigqkfgllqvktilatafrsydfql
lrdevpdpdyhtmvvgptasqcrvkyirrk

Timeline for d3tikd_:

• d3tikd_ first appeared in SCOPe 2.02
  
• d3tikd_ appears in SCOPe 2.04
  
• d3tikd_ appears in the current release, SCOPe 2.08, called d3tikd1