SCOPe 2.08: Domain d3tika1: 3tik A:32-477

Lineage for d3tika1 (3tik A:32-477)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [194968] (9 PDB entries)

8. Domain d3tika1: 3tik A:32-477 [194971]
   Other proteins in same PDB: d3tika2, d3tikb2, d3tikc2, d3tikd2
   automated match to d3l4db_
   complexed with hem, jkf

Details for d3tika1

PDB Entry: 3tik, 2.05 Å

PDB Description: Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

PDB Compounds: (A:) sterol 14-alpha demethylase (CYP51)

SCOPe Domain Sequences for d3tika1:

Sequence; same for both SEQRES and ATOM records:

>d3tika1 a.104.1.0 (A:32-477) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
ppvypvtvpilghiiqfgksplgfmqeckrqlksgiftinivgkrvtivgdphehsrffl
prnevlsprevysfmvpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaanwdkdegeinlledcstmiintacqclfgedlrkrldarrfaqllakmesslipa
avflpillklplpqsarcheartelqkilseiiiarkeeevnkdsstsdllsgllsavyr
dgtpmslhevcgmivaamfagqhtssitttwsmlhlmhpanvkhlealrkeieefpaqln
ynnvmdempfaercaresirrdppllmlmrkvmadvkvgsyvvpkgdiiacspllshhde
eafpeprrwdperdekvegafigfgagvhkcigqkfgllqvktilatafrsydfqllrde
vpdpdyhtmvvgptasqcrvkyirrk

Timeline for d3tika1:

• d3tika1 first appeared in SCOPe 2.02, called d3tika_
  
• d3tika1 appears in SCOPe 2.07