SCOPe 2.08: Domain d4fxza_: 4fxz A:

Lineage for d4fxza_ (4fxz A:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (3 families)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (43 PDB entries)
   Uniprot O67854 5-513

8. Domain d4fxza_: 4fxz A: [194840]
   automated match to d2q6ha_
   complexed with act, leu, na, und

Details for d4fxza_

PDB Entry: 4fxz, 2.6 Å

PDB Description: Crystal structure of LeuT-F253A bound to L-leucine from lipid bicelles

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d4fxza_:

Sequence, based on SEQRES records:

>d4fxza_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqifatlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrn

Sequence, based on observed residues (ATOM records):

>d4fxza_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirgi
skgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwiaa
vgqifatlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaffg
vanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiafl
edelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwif
gadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwitr
fyiiglflfltflvflaerrrn

Timeline for d4fxza_:

• d4fxza_ first appeared in SCOPe 2.02
  
• d4fxza_ appears in SCOPe 2.07