Lineage for d4ag8a_ (4ag8 A:)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671838Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1673984Protein automated matches [190091] (13 species)
    not a true protein
  7. 1674055Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)
  8. 1674197Domain d4ag8a_: 4ag8 A: [194652]
    automated match to d2p2ha_
    complexed with axi

Details for d4ag8a_

PDB Entry: 4ag8 (more details), 1.95 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with axitinib (ag-013736) (n-methyl-2-(3-((e)-2-pyridin-2-yl-vinyl)-1h- indazol-6- ylsulfanyl)-benzamide)
PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d4ag8a_:

Sequence, based on SEQRES records: (download)

>d4ag8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgasp
ypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq
ana

Sequence, based on observed residues (ATOM records): (download)

>d4ag8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglard
iykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkid
eefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqana

SCOPe Domain Coordinates for d4ag8a_:

Click to download the PDB-style file with coordinates for d4ag8a_.
(The format of our PDB-style files is described here.)

Timeline for d4ag8a_: