SCOPe 2.02: Domain d4ag8a_: 4ag8 A:

Lineage for d4ag8a_ (4ag8 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (10 species)
   not a true protein

7. Species Homo sapiens [TaxId:9606] [192729] (55 PDB entries)

8. Domain d4ag8a_: 4ag8 A: [194652]
   automated match to d2p2ha_
   complexed with axi

Details for d4ag8a_

PDB Entry: 4ag8, 1.95 Å

PDB Description: crystal structure of the vegfr2 kinase domain in complex with axitinib (ag-013736) (n-methyl-2-(3-((e)-2-pyridin-2-yl-vinyl)-1h- indazol-6- ylsulfanyl)-benzamide)

PDB Compounds: (A:) Vascular endothelial growth factor receptor 2

SCOPe Domain Sequences for d4ag8a_:

Sequence, based on SEQRES records:

>d4ag8a_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
hcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkic
dfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgasp
ypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllq
ana

Sequence, based on observed residues (ATOM records):

>d4ag8a_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
hcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglard
iykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkid
eefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqana

Timeline for d4ag8a_:

• d4ag8a_ is new in SCOPe 2.02-stable
  
• d4ag8a_ appears in SCOPe 2.03
  
• d4ag8a_ appears in the current release, SCOPe 2.08