SCOPe 2.04: Domain d4b1ca_: 4b1c A:

Lineage for d4b1ca_ (4b1c A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d4b1ca_: 4b1c A: [194565]
   automated match to d1fkna_
   complexed with 1b1, dms

Details for d4b1ca_

PDB Entry: 4b1c, 1.95 Å

PDB Description: new aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4b1ca_:

Sequence; same for both SEQRES and ATOM records:

>d4b1ca_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp
vedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrta
avegpfvtledcgyn

Timeline for d4b1ca_:

• d4b1ca_ first appeared in SCOPe 2.02
  
• d4b1ca_ appears in SCOPe 2.03
  
• d4b1ca_ appears in SCOPe 2.05
  
• d4b1ca_ appears in the current release, SCOPe 2.08