Lineage for d2pzpa_ (2pzp A:)

  1. Root: SCOPe 2.02
  2. 1190016Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1220003Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1220004Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1220070Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1221476Protein automated matches [190091] (10 species)
    not a true protein
  7. 1221597Species Human (Homo sapiens) [TaxId:9606] [188447] (293 PDB entries)
  8. 1221803Domain d2pzpa_: 2pzp A: [194442]
    automated match to d3b2tb_
    complexed with acp, mg, so4; mutant

Details for d2pzpa_

PDB Entry: 2pzp (more details), 2.4 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k526e mutation responsible for crouzon syndrome
PDB Compounds: (A:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d2pzpa_:

Sequence, based on SEQRES records: (download)

>d2pzpa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddateed
lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmeys
ydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfgl
ardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgi
pveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlttn

Sequence, based on observed residues (ATOM records): (download)

>d2pzpa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddateedlsdlvs
ememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpeeqmtfkdlvsc
tyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngrlp
vkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpa
nctnelymmmrdcwhavpsqrptfkqlvedldriltlttn

SCOPe Domain Coordinates for d2pzpa_:

Click to download the PDB-style file with coordinates for d2pzpa_.
(The format of our PDB-style files is described here.)

Timeline for d2pzpa_: