SCOPe 2.08: Domain d2pwla_: 2pwl A:

Lineage for d2pwla_ (2pwl A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 2 [75562] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75563] (16 PDB entries)
   Uniprot P21802 467-765

8. Domain d2pwla_: 2pwl A: [194430]
   automated match to d3b2tb_
   complexed with acp, so4; mutant

Details for d2pwla_

PDB Entry: 2pwl, 2.4 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic n549h mutation responsible for crouzon syndrome.

PDB Compounds: (A:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d2pwla_:

Sequence, based on SEQRES records:

>d2pwla_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
dlsdlvsememmkmigkhkniihllgactqdgplyviveyaskgnlreylrarrppgmey
sydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfg
lardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypg
ipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Sequence, based on observed residues (ATOM records):

>d2pwla_ d.144.1.7 (A:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
dlsdlvsememmkmigkhkniihllgactqdgplyviveyaskgnlreylrarrpeqmtf
kdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkt
tngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkegh
rmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Timeline for d2pwla_:

• d2pwla_ first appeared in SCOPe 2.02
  
• d2pwla_ appears in SCOPe 2.07