SCOPe 2.08: Domain d1ezfb_: 1ezf B:

Lineage for d1ezfb_ (1ezf B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.2: Squalene synthase [48580] (2 proteins)
   automatically mapped to Pfam PF00494

6. Protein Squalene synthase [48581] (1 species)
   synonym: Farnesyl diphosphate farnesyltransferase

7. Species Human (Homo sapiens) [TaxId:9606] [48582] (1 PDB entry)

8. Domain d1ezfb_: 1ezf B: [19441]
   complexed with in0

Details for d1ezfb_

PDB Entry: 1ezf, 2.15 Å

PDB Description: crystal structure of human squalene synthase

PDB Compounds: (B:) farnesyl-diphosphate farnesyltransferase

SCOPe Domain Sequences for d1ezfb_:

Sequence, based on SEQRES records:

>d1ezfb_ a.128.1.2 (B:) Squalene synthase {Human (Homo sapiens) [TaxId: 9606]}
nslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekk
vpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgig
maefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqk
tniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdv
itylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpa
vkaiiyqymeeiyhripdsdpsssktrqiistirtqn

Sequence, based on observed residues (ATOM records):

>d1ezfb_ a.128.1.2 (B:) Squalene synthase {Human (Homo sapiens) [TaxId: 9606]}
nslsnslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekk
vpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgig
maefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqk
tniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdv
itylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavatnmpavkaiiyqymeeiy
hripdsdpsssktrqiistirtqn

Timeline for d1ezfb_:

• d1ezfb_ first appeared (with stable ids) in SCOP 1.55
  
• d1ezfb_ appears in SCOPe 2.07