Lineage for d4i22a_ (4i22 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2543502Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2543503Species Human (Homo sapiens) [TaxId:9606] [82796] (109 PDB entries)
    Uniprot P00533 702-1018
  8. 2543518Domain d4i22a_: 4i22 A: [194134]
    automated match to d1m14a_
    complexed with ire, so4; mutant

Details for d4i22a_

PDB Entry: 4i22 (more details), 1.71 Å

PDB Description: structure of the monomeric (v948r)gefitinib/erlotinib resistant double mutant (l858r+t790m) egfr kinase domain co-crystallized with gefitinib
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4i22a_:

Sequence, based on SEQRES records: (download)

>d4i22a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvpik
wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
tidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyr
almdeedmddvvdad

Sequence, based on observed residues (ATOM records): (download)

>d4i22a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrkankeildeay
vmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakg
mnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllvpikwmalesilhriythqsdv
wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidads
rpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad

SCOPe Domain Coordinates for d4i22a_:

Click to download the PDB-style file with coordinates for d4i22a_.
(The format of our PDB-style files is described here.)

Timeline for d4i22a_: